Glucosamine HCL With MSM from NBC Pharmacy

GLUCOSAMINE is one of the major building blocks utilized in the body's synthesis of the lubricants and shock absorbing mechanisms necessary to maintain and restore healthy joint performance.

GLUCOSAMINE supplementation enhances the body's ability to manufacture collagen and proteoglycans which are essential for rebuilding joints, as well as synovial fluid which lubricate your joints.

MSM offers pain and stiffness relief, reduces swelling and acts as an anti-inflammatory. MSM (Methylsulfonylmethane) is not a medicine or a drug. MSM is a food - a pure white sulfur powder. MSM comes from the ocean and is water soluble. Sulfonyl sulfur is found in plants, meats, dairy products and vegetation. Reports claim that MSM improves the chemical profile of arthritic patients by providing pain and stiffness relief, reducing swelling and inflammation coupled with a return of blood chemistry toward normalcy. Our Glucosamine HCL With MSM is recommended by some of the finest physical therapy clinics in America.

Glucosamine is naturally present in the body, and is found in most of the foods we eat. Glucosamine is one of the major building blocks utilized in the body’s synthesis of the lubricants and shock absorbing mechanisms necessary to maintain and restore healthy joint performance Glucosamine supplementation enhances the ability of the body to manufacture collagen and proteoglycans which are essential for rebuilding joints, as well as synovial fluid which lubricates your joints. (1, 2, 3)

Glucosamine HCL preferred over Glucosamine sulfate

The difference in these two products lies in how they are manufactured. Glucosamine HCL is a 99% pure product. When Glucosamine sulfate is manufactured it is very hygroscopic and degrades rapidly when exposed to moisture. To avoid this, the Glucosamine sulfate, as currently imported, is made from Glucosamine HCL by adding either sodium or potassium sulfate and co-crystallizing the resulting mixture. Thus, most of the Glucosamine sulfate imported into the U.S. is only 80% pure with the remainder being sodium or potassium chloride. This difference in purity means that you have to take more Glucosamine sulfate to get the same effect as you would get with a smaller dose of Glucosamine HCL, and there is a significant intake of salt.

MSM - provides pain and stiffness relief, reduced swelling and inflammation

MSM (Methylsulfonylmethane) is not a medicine, a drug, or a food additive. It is a FOOD—a pure white sulfur powder. It comes from the ocean and is water soluble. Sulfonyl sulfur is found in plants, meats, dairy products, and vegetation. Reports claim that it improves the chemical profile of arthritic patients (e.g. provides pain and stiffness relief, reduced swelling and inflammation, coupled with a return of blood chemistry toward normalcy). (4)

MSM is a nutritional supplement rapidly establishing a reputation as a safe, natural and effective solution for many types of pain and inflammatory conditions, including:

» Osteoarthritis	» Chronic headaches	» Tendonitis and bursitis
» Rheumatoid arthritis	» Muscle pain	» Carpal tunnel syndrome
» Chronic back pain	» Fibromyalgia	» TMJ

We are now starting to see MSM being added to Glucosamine products. It may be that a combination of the both offers synergistic value and may be more beneficial than when taken alone or apart from each other. (10)

Scientific research indicates that chondroitin is generally not well absorbed

“In my experience, chondroitin sulfate, another nutritional supplement said to promote healthy cartilage, has not proven to offer any significant clinical benefits. Scientific research indicates that chondroitin is generally not well absorbed. (10) Much debate and controversy have followed concerning the questions about Glucosamine and chondroitin. The research has shown there is no additional benefit provided by a combination of Glucosamine and chondroitin versus Glucosamine supplements alone.

The absorption rate of Glucosamine supplements is 90% to 98%, the absorption of intact chondroitin sulfate is estimated to be less than 13%. (5-8) The difference in absorption is largely due to the difference in size. “Chondroitin sulfate is at least 50-300 times larger than Glucosamine sulfate, too large to pass the normal intact intestinal barrier. If chondroitin molecules were absorbed intact or partially digested, they are still unlikely to produce any significant benefit, as the chondroitin sulfate molecules are too large to be delivered to cartilage cells. These results prompted the researchers to conclude that, “chondroprotection by orally administered chondroitin sulfate is a biologically and pharmacologically unfounded theory.” (7) “Therefore any direct action of orally administered chondroitin sulfate on cartilage and chondrocytes is not possible.” (9)

Bibliography/References

“Effect of Hesosamines on the synthesis of Chorondroitin Sulphuric Acid in Vitro,” Lennart Roden, Arkiv for Kemi Band 10 nr 23 (1956)

“Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminogylcane Metabolism of Fibroblast Cultures,” K. Karzel and R. Dokmenjoz; Pharmacology 5: 335-337 (1971)

“Effects of D-Glucosamine Concentration on the Kinetics of Mucopolysaccharide Biosynthesis in Cultured Chick Embryo Bertebral Cartilage,” Jau Ja Kim and H. Howard; The Journal of Biological Chemistry, Vol. 249, No. 10, Issue of May 25, PP.3091-3097 (1974)

“Glucosamine and Chondroitin,” Dr. Bradley Bongiovanni, ND. Wellness Web Homepage (Sept. 15, 1999)

Setnikar, I, et al.; “Pharmocokinetics of glucosamine in man.” Arzniem Forsch 43(10):1109-13. 1993.

Setnikar, I, et al.: “Pharmocokinetics of glucosamine in the dog and man.” Arzniem Forsch 36(4):729-35, 1986.

Baici A, et al.: “Analysis of hlycosaminoglycans in human sera after oral administration of chondroitin sulphate.” Rheumatol Int 12:81-8, 1992.

Conte A, et al.: “”Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulphate.” Arzzniem Forsch 45:918-25, 1995.

Baici A. and Wagenhauser F.J.: “Bioavailability of oral chondroitin soleplate.” Rheumatol Int. 13:41-43, 1993.

Jacob M.D., Lawrence, M.D., Ph.D., Zucker M.D.: “The Miracle of MSM The Natural Solution for Pain”. Putnam, New York, 1999.